CARDIOVASCULAR EFFECTS OF CHLORMETHIAZOLE

A study of the cardiovascular effects of chlormethiazole.

A study of the cardiovascular effects of intravenous chlormethiazole (Heminevrin) was carried out on five volunteers. It showed that induction of light anaesthesia was easy, maintenance easy, and the recovery period short and uneventful. During induction, maintenance and recovery the only cardiovascular disturbance noted was an increase in heart rate; cardiac output was maintained at the pre-in...

Attenuation by chlormethiazole

1 In vivo microdialysis has been used to investigate the concentration of various amino acids and lactate in the extracellular fluid of the rat cortex following focal ischaemia, the probe being placed in the core of the infarct area. 2 An ischaemic infarct was produced in the cortex by use of a photochemical dye (Rose Bengal) and light irradiation. There was a marked increase in lactate concent...

Cardiovascular Effects of Acute Organophosphate Poisoning

Background:Cardiovascular effects of acute organophosphate (OP) poisoning are common. This study was aimed to assess the cardiovascular effects of OP poisoned patients in Nepal. Methods:This was a prospective hospital-based cross-sectional study of 115 acute OP poisoned patients presenting in emergency department of a tertiary care teaching hospital of central Nepal during November 2008 to Octo...

Chlormethiazole, sleep, and drug withdrawal.

Chlormethiazole in treatment of status epilepticus.

Chlormethiazole (Heminevrin) was successful in controlling fits in seven out of nine episodes of intractable status epilepticus. It was administered as a constant intravenous injection at rates of up to 0.7g/h. No serious side effects were encountered, and the drug deserves wider recognition as a useful therapeutic agent in the management of status epilepticus.